P-cadherin induces anoikis-resistance of matrix-detached breast cancer cells by promoting pentose phosphate pathway and decreasing oxidative stress

Successful metastatic spreading relies on cancer cells with stem-like properties, glycolytic metabolism and increased antioxidant protection, allowing them to escape anoikis and to survive in circulation. The expression of P-cadherin, a poor prognostic factor in breast cancer, is associated with hyp...

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Detalhes bibliográficos
Autor principal: Sousa, Bárbara (author)
Outros Autores: Pereira, Joana (author), Marques, Ricardo (author), Grilo, Luís F (author), Pereira, Susana P (author), Oliveira, Vilma Marisa Arrojado Soares Sardão (author), Schmitt, Fernando (author), Oliveira, Paulo J (author), Paredes, Joana Cancela de Amorim Falcão (author)
Formato: article
Idioma:por
Publicado em: 2020
Assuntos:
Antioxidant; Breast cancer; Matrix-detached; Oxidative stress; P-cadherin; anoikis-resistant
Breast Neoplasms
Cadherins
Extracellular Matrix
Female
Humans
Pentose Phosphate Pathway
Reactive Oxygen Species
Tumor Cells, Cultured
Anoikis
Oxidative Stress
Texto completo:http://hdl.handle.net/10316/101006
País:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/101006

Texto Completo

http://hdl.handle.net/10316/101006

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