Developing of novel therapeutics for breast cancer: targeting the Notch ligand DLL1
"Breast cancer (BC) is the second main cause of cancer related deaths for women worldwide. Despite significant advances in BC treatment, it remains a considerable clinical challenge and there is an unmet need to design new and more effective drugs to treat this disease. The Notch signaling path...
| Main Author: | |
|---|---|
| Format: | doctoralThesis |
| Language: | eng |
| Published: |
2021
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10362/121639 |
| Country: | Portugal |
| Oai: | oai:run.unl.pt:10362/121639 |
| Summary: | "Breast cancer (BC) is the second main cause of cancer related deaths for women worldwide. Despite significant advances in BC treatment, it remains a considerable clinical challenge and there is an unmet need to design new and more effective drugs to treat this disease. The Notch signaling pathway is an evolutionary conserved cell-to-cell communication system involved in a multitude of cellular processes, such as stem cell self-renewal, cellular homeostasis, proliferation, migration and apoptosis, playing an important role in normal breast biology.(...)" |
|---|