In vitro susceptibility of Leishmania infantum to Artemisinin derivatives and selected trioxolanes

Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and int...

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Bibliographic Details
Main Author: Cortes, Sofia (author)
Other Authors: Albuquerque, Andreia (author), Cabral, Lília (author), Lopes, Liliana (author), Campino, Lenea (author), Cristiano, Maria L. S. (author)
Format: article
Language:eng
Published: 2018
Subjects:
Synthetic Trioxolane
Antimalarial
Dispiro-1,2,4-Trioxolanes
Chemotherapy
Peroxides
Online Access:http://hdl.handle.net/10400.1/11151
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/11151
Description
Summary:Leishmaniasis is among the world's most neglected diseases. Currently available drugs for treatment present drawbacks, urging the need for more effective, safer, and cheaper drugs. A small library of artemisinin-derived trioxanes and synthetic trioxolanes was tested against promastigote and intramacrophage amastigote forms of Leishmania infantum. The trioxolanes LC50 and LC95 presented the best activity and safety profiles, showing potential for further studies in the context of leishmanial therapy. Our results indicate that the compounds tested exhibit peroxide-dependent activity.

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