Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies

Recently, thioxanthone derivatives were found to protect cells against toxic P-glycoprotein (P-gp) substrates, acting as potent inducers/activators of this efflux pump. The study of new P-gp chiral modulators produced from thioxanthone derivatives could clarify the enantioselectivity of this ABC tra...

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Bibliographic Details
Main Author: Lopes A. (author)
Other Authors: Martins E. (author), Silva R. (author), Pinto M.M.M. (author), Remião F. (author), Sousa E. (author), Fernandes C. (author)
Format: article
Language:eng
Published: 2018
Subjects:
multidrug resistance protein 1
rhodamine 123
thioxanthene derivative
thioxanthone
xanthone derivative
Caco-2 cell line
chemical structure
chemistry
human
metabolism
synthesis
upregulation
ATP-Binding Cassette, Sub-Family B, Member 1
Caco-2 Cells
Humans
Molecular Structure
Rhodamine 123
Thioxanthenes
Up-Regulation
Xanthones
Online Access:https://hdl.handle.net/10216/120484
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/120484

Internet

https://hdl.handle.net/10216/120484

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