Hybrid alginate-based cryogels for life science applications

This work presents a novel route toward porous scaffolds for tissue engineering and regenerative medicine (TERM) appli- cations. Hybrid cryogels with gelatin, gellan gum, carboxymethylcellulose, and lignin were prepared by a two-step process. Textural properties of the cryogels were analyzed by SEM...

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Detalhes bibliográficos
Autor principal: Barros, Alexandre António Antunes (author)
Outros Autores: Quraishi, Sakeena (author), Martins, Marta (author), Gurikov, Pavel (author), Subrahmanyam, Raman (author), Smirnova, Irina (author), Duarte, Ana Rita C. (author), Reis, R. L. (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
Alginate-based
CO2 gelation
Cryogels
Freeze-drying
Alginate
Cryogel
Science & Technology
Texto completo:http://hdl.handle.net/1822/42480
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/42480
Descrição
Resumo:This work presents a novel route toward porous scaffolds for tissue engineering and regenerative medicine (TERM) appli- cations. Hybrid cryogels with gelatin, gellan gum, carboxymethylcellulose, and lignin were prepared by a two-step process. Textural properties of the cryogels were analyzed by SEM and micro-computed tomography. The results indicated that rapid freezing retained sample shape and yielded macroporous materials. The mechanical properties of the cryogels were characterized in compression mode. Cytotoxicity studies indicated that the hybrid-alginate cryogels did not present cyto- toxicity and have the potential to be used in TERM.

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