Hybrid alginate-based cryogels for life science applications

This work presents a novel route toward porous scaffolds for tissue engineering and regenerative medicine (TERM) appli- cations. Hybrid cryogels with gelatin, gellan gum, carboxymethylcellulose, and lignin were prepared by a two-step process. Textural properties of the cryogels were analyzed by SEM...

Full description

Bibliographic Details
Main Author: Barros, Alexandre António Antunes (author)
Other Authors: Quraishi, Sakeena (author), Martins, Marta (author), Gurikov, Pavel (author), Subrahmanyam, Raman (author), Smirnova, Irina (author), Duarte, Ana Rita C. (author), Reis, R. L. (author)
Format: article
Language:eng
Published: 2016
Subjects:
Alginate-based
CO2 gelation
Cryogels
Freeze-drying
Alginate
Cryogel
Science & Technology
Online Access:http://hdl.handle.net/1822/42480
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/42480
Description
Summary:This work presents a novel route toward porous scaffolds for tissue engineering and regenerative medicine (TERM) appli- cations. Hybrid cryogels with gelatin, gellan gum, carboxymethylcellulose, and lignin were prepared by a two-step process. Textural properties of the cryogels were analyzed by SEM and micro-computed tomography. The results indicated that rapid freezing retained sample shape and yielded macroporous materials. The mechanical properties of the cryogels were characterized in compression mode. Cytotoxicity studies indicated that the hybrid-alginate cryogels did not present cyto- toxicity and have the potential to be used in TERM.

Similar Items