The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates

Differentiation of the presynaptic terminal is a complex and rapid event that normally occurs in spatially specific axonal regions distant from the soma; thus, it is believed to be dependent on intra-axonal mechanisms. However, the full nature of the local events governing presynaptic assembly remai...

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Bibliographic Details
Main Author: Pinto, Maria J. (author)
Other Authors: Alves, Pedro L. (author), Martins, Luís (author), Pedro, Joana R. (author), Ryu, Hyun R. (author), Jeon, Noo Li (author), Taylor, Anne M. (author), Almeida, Ramiro D. (author)
Format: article
Language:eng
Published: 2017
Subjects:
Animals
Axons
Cells, Cultured
Hippocampus
Luminescent Proteins
Microscopy, Fluorescence
Polyubiquitin
Presynaptic Terminals
Proteasome Endopeptidase Complex
Proteasome Inhibitors
Proteolysis
Rats, Wistar
Recombinant Fusion Proteins
Signal Transduction
Synaptic Vesicles
Time Factors
Time-Lapse Imaging
Transfection
Ubiquitinated Proteins
Ubiquitination
Cell Differentiation
Online Access:http://hdl.handle.net/10400.22/9192
Country:Portugal
Oai:oai:recipp.ipp.pt:10400.22/9192

Internet

http://hdl.handle.net/10400.22/9192

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