SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy

SNCA (α-synuclein) misfolding and aggregation is strongly associated with both idiopathic and familial forms of Parkinson disease (PD). Evidence suggests that SNCA has an impact on cell clearance routes and protein quality control systems such as the ubiquitin-proteasome system (UPS) and autophagy....

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Detalhes bibliográficos
Autor principal: Marques, Belém Sampaio (author)
Outros Autores: Felgueiras, Carolina (author), Silva, Alexandra (author), Rodrigues, Márcio (author), Tenreiro, Sandra (author), Franssens, Vanessa (author), Reichert, Andreas S. (author), Outeiro, Tiago F. (author), Winderickx, Joris (author), Ludovico, Paula (author)
Formato: article
Idioma:eng
Publicado em: 2012
Assuntos:
lpha-synuclein
Autophagy
Mitophagy
Sirtuins
Chronological aging
Yeast
Synucleinopathies
alpha-synuclein
Science & Technology
Texto completo:http://hdl.handle.net/1822/21186
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/21186

Texto Completo

http://hdl.handle.net/1822/21186

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