SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy

SNCA (α-synuclein) misfolding and aggregation is strongly associated with both idiopathic and familial forms of Parkinson disease (PD). Evidence suggests that SNCA has an impact on cell clearance routes and protein quality control systems such as the ubiquitin-proteasome system (UPS) and autophagy....

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Bibliographic Details
Main Author: Marques, Belém Sampaio (author)
Other Authors: Felgueiras, Carolina (author), Silva, Alexandra (author), Rodrigues, Márcio (author), Tenreiro, Sandra (author), Franssens, Vanessa (author), Reichert, Andreas S. (author), Outeiro, Tiago F. (author), Winderickx, Joris (author), Ludovico, Paula (author)
Format: article
Language:eng
Published: 2012
Subjects:
lpha-synuclein
Autophagy
Mitophagy
Sirtuins
Chronological aging
Yeast
Synucleinopathies
alpha-synuclein
Science & Technology
Online Access:http://hdl.handle.net/1822/21186
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/21186

Internet

http://hdl.handle.net/1822/21186

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