Mitochondria Fusion upon SERCA Inhibition Prevents Activation of the NLRP3 Inflammasome in Human Monocytes

Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) is a crucial component of the cellular machinery responsible for Ca2+ homeostasis. The selective inhibition of SERCA by thapsigargin (TG) leads to perturbations in Ca2+ signaling, which can trigger endoplasmic reticulum (ER) stress. The unfolded protei...

Full description

Bibliographic Details
Main Author: Pereira, Ana Catarina (author)
Other Authors: Madeira, Nuno (author), Morais, Sofia (author), Macedo, António (author), Cruz, Maria Teresa (author), Pereira, Cláudia M. F. (author)
Format: article
Language:eng
Published: 2022
Subjects:
calcium homeostasis
endoplasmic reticulum (ER) stress
immune system
sterile inflammation
mitochondria dynamics
Humans
Inflammation
Mitochondria
Monocytes
Thapsigargin
Inflammasomes
Mitochondrial Dynamics
NLR Family, Pyrin Domain-Containing 3 Protein
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Online Access:http://hdl.handle.net/10316/103215
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/103215

Internet

http://hdl.handle.net/10316/103215

Similar Items