Synthesis and structure-activity relationships of novel ecdysteroid dioxolanes as MDR modulators in cancer.
Ecdysteroids, molting hormones of insects, can exert several mild, non-hormonal bioactivities in mammals, including humans. In a previous study, we have found a significant effect of certain derivatives on the ABCB1 transporter mediated multi-drug resistance of a transfected murine leukemia cell lin...
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| Format: | article |
| Language: | und |
| Published: |
2021
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| Online Access: | http://hdl.handle.net/10362/116941 |
| Country: | Portugal |
| Oai: | oai:run.unl.pt:10362/116941 |
| Summary: | Ecdysteroids, molting hormones of insects, can exert several mild, non-hormonal bioactivities in mammals, including humans. In a previous study, we have found a significant effect of certain derivatives on the ABCB1 transporter mediated multi-drug resistance of a transfected murine leukemia cell line. In this paper, we present a structure-activity relationship study focused on the apolar dioxolane derivatives of 20-hydroxyecdysone. Semi-synthesis and bioactivity of a total of 32 ecdysteroids, including 20 new compounds, is presented, supplemented with their complete 1H- and 13C-NMR signal assignment. |
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