Different pathways and biomarkers of acute and chronic cyclosporineinduced nephrotoxicity in a rat model: focus on overexpression of mTOR and Mki67

Calcineurin inhibitors, in particular Cyclosporin A (CsA), remains the cornerstones of immunosuppressive regimens in many transplantation centres worldwide, regardless of drug-induced nephrotoxicity. The pathogenesis of CsA-induced nephropathy remains to be fully elucidated, but seems to be affected...

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Bibliographic Details
Main Author: Sereno,Jose (author)
Other Authors: Rodrigues-Santos,Paulo (author), Vala,Helena (author), Parada,Belmiro (author), Alves,Rui (author), Teixeira-Lemos,Edite (author), Rocha-Pereira,Petronila (author), Teixeira,Frederico (author), Reis,Flavio (author)
Format: article
Language:eng
Published: 2013
Subjects:
acute and chronic cyclosporine-induced nephrotoxicity
biomarkers
gene expression
histology
rat model
Online Access:http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000300009
Country:Portugal
Oai:oai:scielo:S0872-01692013000300009

Internet

http://scielo.pt/scielo.php?script=sci_arttext&pid=S0872-01692013000300009

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