Expression of DUSP4 transcript variants as a potential biomarker for colorectal cancer

Aim: To provide novel data on the expression of DUSP4 transcripts in colorectal cancer (CRC) tissues and to explore their potential as biomarkers. Materials & methods:DUSP4 transcripts expression was determined by quantitative real-time PCR in tissues from 28 CRC patients. Their association with...

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Bibliographic Details
Main Author: Varela, Tatiana (author)
Other Authors: Laizé, Vincent (author), Conceição, Natércia (author), Caldeira, Paulo (author), Marreiros, Ana (author), Guerreiro, Horacio (author), Cancela, M. Leonor (author)
Format: article
Language:eng
Published: 2021
Subjects:
Biomarker
Colorectal cancer
DUSP4
Gene expression
Transcript variants
Research & Experimental Medicine
Online Access:http://hdl.handle.net/10400.1/16460
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/16460
Description
Summary:Aim: To provide novel data on the expression of DUSP4 transcripts in colorectal cancer (CRC) tissues and to explore their potential as biomarkers. Materials & methods:DUSP4 transcripts expression was determined by quantitative real-time PCR in tissues from 28 CRC patients. Their association with clinicopathological factors and survival analysis was performed. Data from 380 CRC patients available at The Cancer Genome Atlas project were also analyzed. Results: All transcripts were overexpressed in CRC tissues. Variant X1 was the most upregulated and associated with KRAS mutations and poorly differentiated tumor. Overexpression of DUSP4 transcripts could distinguish all tumor stages from normal tissues. Similar results were found in The Cancer Genome Atlas cohort. Conclusion:DUSP4 transcripts have the potential to serve as diagnostic biomarkers for CRC, particularly variant X1.

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