DIVERSet JAG compounds inhibit topoisomerase II and are effective against adult and pediatric high-grade gliomas

High-grade gliomas (HGGs) are aggressive primary brain tumors with local invasive growth and poor clinical prognosis in both adult and pediatric patients. Clinical response is compounded by resistance to standard frontline antineoplastic agents, an absence of novel therapeutics, and poor in vitro mo...

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Bibliographic Details
Main Author: Howarth, Alison (author)
Other Authors: Simms, Claire (author), Kerai, Nitesh (author), Allen, Olivia (author), Mihajluk, Karina (author), Madureira, Patricia (author), Sokratous, Giannis (author), Cragg, Simon (author), Lee, Sang Y. (author), Morley, Andy D. (author), Ashkan, Keyoumars (author), Cox, Paul A. (author), Pilkington, Geoffrey J. (author), Hill, Richard (author)
Format: article
Language:eng
Published: 2020
Subjects:
Brain-stem glioma
Vincristine chemotherapy
Online Access:http://hdl.handle.net/10400.1/13459
Country:Portugal
Oai:oai:sapientia.ualg.pt:10400.1/13459

Internet

http://hdl.handle.net/10400.1/13459

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