BAG-1 stabilizes mutant F508del-CFTR in a Ubiquitin-Like-Domain-Dependent Manner

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), the dysfunctional Cl- channel in Cystic Fibrosis, undergoes complex biosynthesis at the endoplasmic reticulum involving several molecular chaperones including Hsp70 and many co-chaperones. Bcl-2-associated athanogenes (BAGs) constitute a pr...

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Bibliographic Details
Main Author: Mendes, Filipa (author)
Other Authors: Farinha, Carlos M. (author), Felício, Verónica (author), Alves, Paula C. (author), Vieira, Isabel (author), Amaral, Paulo C. (author)
Format: article
Language:eng
Published: 2013
Subjects:
Fibrose Quística
CFTR
ERAD
BAG-1
Hsp70
Ubiquitina
Doenças Genéticas
Online Access:http://hdl.handle.net/10400.18/1533
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/1533

Internet

http://hdl.handle.net/10400.18/1533

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