Mycobacterium ulcerans Triggers T-cell immunity followed by local and regional but not systemic immunosuppression

Buruli ulcer (BU) is a neglected infectious disease caused by Mycobacterium ulcerans, characterized by necrotic cutaneous lesions induced by the exotoxin mycolactone. Despite evidence of Th1-mediated protective immunity, M. ulcerans infection has been associated with systemic immunosuppression. We s...

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Bibliographic Details
Main Author: Fraga, Alexandra G. (author)
Other Authors: Cruz, Andrea (author), Martins, Teresa G. (author), Torrado, Egídio (author), Saraiva, Margarida (author), Pereira, Daniela Maria Ramos (author), Meyers, Wayne M. (author), Portaels, Françoise (author), Silva, Manuel T. (author), Castro, António G. (author), Pedrosa, Jorge (author)
Format: article
Language:eng
Published: 2011
Subjects:
Buruli ulcer
Science & Technology
Online Access:http://hdl.handle.net/1822/18746
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/18746

Internet

http://hdl.handle.net/1822/18746

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