Generation of Nonmosaic, Two-Pore Channel 2 Biallelic Knockout Pigs in One Generation by CRISPR-Cas9 Microinjection Before Oocyte Insemination

Abstract Studies of knockout (KO) mice with defects in the endolysosomal two-pore channels (TPCs) have shown TPCs to be involved in pathophysiological processes, including heart and muscle function, metabolism, immunity, cancer, and viral infection. With the objective of studying TPC2’s pathophysiol...

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Bibliographic Details
Main Author: Navarro-Serna, Sergio (author)
Other Authors: Hachem, Alaa (author), Canha-Gouveia, Analuce (author), Hanbashi, Ali (author), Garrapa, Gabriela (author), Lopes, Jordana S. (author), París-Oller, Evelyne (author), Sarrías-Gil, Lucia (author), Flores-Flores, Cesar (author), Basset, Andrew (author), Sánchez, Raul (author), Bermejo-Alcarez, Pablo (author), Matás, Carmen (author), Romar, Raquel (author), Parrington, John (author), Gadea, Joaquin (author)
Format: article
Language:eng
Published: 2022
Subjects:
Cripr-Cas9
TPC2
KO pigs
Online Access:http://hdl.handle.net/10174/31615
Country:Portugal
Oai:oai:dspace.uevora.pt:10174/31615

Internet

http://hdl.handle.net/10174/31615

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