GABA release by basket cells onto Purkinje cells, in rat cerebellar slices, is directly controlled by presynaptic purinergic receptors, modulating Ca2+ influx

In many brain regions, Ca2+ influx through presynaptic P2X receptors influences GABA release from interneurones. In patch-clamp recordings of Purkinje cells (PCs) in rat cerebellar slices, broad spectrum P2 receptor antagonists, PPADS (30 [mu]M) or suramin (12 [mu]M), result in a decreased amplitude...

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Bibliographic Details
Main Author: Donato, Roberta (author)
Other Authors: Rodrigues, Ricardo J. (author), Takahashi, Michiko (author), Tsai, Ming Chi (author), Soto, David (author), Miyagi, Kana (author), Villafuertes, Rosa Gomez (author), Cunha, Rodrigo A. (author), Edwards, Frances A. (author)
Format: article
Language:eng
Published: 2008
Subjects:
Purkinje cell
Cerebellar cortex
Purinergic
GABA release
Calcium influx
Calcium stores
Synaptic transmission
Presynaptic receptors
Online Access:http://hdl.handle.net/10316/4679
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/4679

Internet

http://hdl.handle.net/10316/4679

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