Protein kinase-mediated regulation of glucose transporters translocation to the plasma membrane

Cancer cells require increased glucose supply to sustain proliferation. One mechanism involves increased expression of glucose transporter (GLUT) genes. But insulin has revealed that protein phosphorylation is another key mechanism in glucose uptake regulation: insulin binding to responsive cells tr...

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Bibliographic Details
Main Author: Henriques, Andreia (author)
Other Authors: Matos, Paulo (author), Jordan, Peter (author)
Format: conferenceObject
Language:eng
Published: 2020
Subjects:
WNK Protein Kinase
Cancer
Signal Transduction
Glucose
Vias de Transdução de Sinal e Patologias Associadas
Online Access:http://hdl.handle.net/10400.18/5795
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5795
Description
Summary:Cancer cells require increased glucose supply to sustain proliferation. One mechanism involves increased expression of glucose transporter (GLUT) genes. But insulin has revealed that protein phosphorylation is another key mechanism in glucose uptake regulation: insulin binding to responsive cells triggers a signalling cascade with phosphorylation of TBC1D4, a negative regulator of endosomal GLUT trafficking, so that more transporters are inserted into the plasma membrane.

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