Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents

Barbituric and thiobarbituric acid derivatives have become progressively attractive to medicinal chemists due to their wide range of biological activities. Herein, different series of 1,3,5-trisubstituted barbiturates and thiobarbiturates were prepared in moderate to excellent yields and their activ...

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Bibliographic Details
Main Author: Figueiredo, Joana (author)
Other Authors: Serrano, João L. (author), Cavalheiro, Eunice Cerdeira Soares (author), Keurulainen, Leena Maria (author), Yli-Kauhaluoma, Jari Tapani (author), Moreira, Vânia M (author), Ferreira, Susana (author), Domingues, F.C. (author), Silvestre, Samuel (author), Almeida, Paulo (author)
Format: article
Language:eng
Published: 2020
Subjects:
Barbiturates
Xanthine oxidase inhibition
Antioxidant
Antibacterial
Cytotoxicity
Online Access:http://hdl.handle.net/10400.6/8883
Country:Portugal
Oai:oai:ubibliorum.ubi.pt:10400.6/8883

Internet

http://hdl.handle.net/10400.6/8883

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