Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness

The gene encoding protein kinase WNK2 was recently identified to be silenced by promoter hypermethylation in gliomas and meningiomas, suggesting a tumour-suppressor role in these brain tumours. Following experimental depletion in cell lines, WNK2 was further found to control GTP-loading of Rac1, a s...

Full description

Bibliographic Details
Main Author: Moniz, Sónia (author)
Other Authors: Martinho, Olga (author), Pinto, Filipe (author), Sousa, Bárbara (author), Loureiro, Cláudia (author), Oliveira, Maria José (author), Moita, Luís Ferreira (author), Honavar, Mrinalini (author), Pinheiro, Célia (author), Pires, Manuel (author), Lopes, José Manuel (author), Jones, Chris (author), Costello, Joseph F (author), Paredes, Joana (author), Reris, Rui Manuel (author), Jordan, Peter (author)
Format: article
Language:eng
Published: 2012
Subjects:
Vias de Transdução de Sinal e Patologias Associadas
Glioma
WNK
Rac1
Invasion
Promoter Methylation
Epigenetic
Online Access:http://hdl.handle.net/10400.18/1132
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/1132

Internet

http://hdl.handle.net/10400.18/1132

Similar Items