Methotrexate and low-dose prednisolone downregulate osteoclast function by decreasing receptor activator of nuclear factor-κβ expression in monocytes from patients with early rheumatoid arthritis

Objective: Rheumatoid arthritis (RA) is a systemic, immune-mediated inflammatory disease that ultimately leads to bone erosions and joint destruction. Methotrexate (MTX) slows bone damage but the mechanism by which it acts is still unknown. In this study, we aimed to assess the effect of MTX and low...

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Bibliographic Details
Main Author: Caetano-Lopes, Joana (author)
Other Authors: Rodrigues, Ana Maria (author), Campanilho-Marques, Raquel (author), Ponte, Cristina (author), Canhão, Helena (author), Ainola, Mari (author), Fonseca, João Eurico (author)
Format: article
Language:eng
Published: 2017
Subjects:
Bone
DMARD
Monocytes
Osteoclast
Rheumatoid arthritis
Rheumatology
Immunology
Immunology and Allergy
Online Access:https://doi.org/10.1136/rmdopen-2016-000365
Country:Portugal
Oai:oai:run.unl.pt:10362/26651

Internet

https://doi.org/10.1136/rmdopen-2016-000365

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