Restoring brain cholesterol turnover improves autophagy and has therapeutic potential in mouse models of spinocerebellar ataxia

Spinocerebellar ataxias (SCAs) are devastating neurodegenerative disorders for which no curative or preventive therapies are available. Deregulation of brain cholesterol metabolism and impaired brain cholesterol turnover have been associated with several neurodegenerative diseases. SCA3 or Machado-J...

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Bibliographic Details
Main Author: Nóbrega, Clévio David Rodrigues (author)
Other Authors: Mendonça, Liliana Simões (author), Marcelo, Adriana Isabel do Vale (author), Lamazière, Antonin (author), Tomé, Sandra Marisa Oliveira (author), Despres, Gaetan (author), Matos, Carlos A (author), Mechmet, Fatich (author), Langui, Dominique (author), den Dunnen, Wilfred (author), Almeida, Luís Pereira de (author), Cartier, Nathalie (author), Alves, Sandro José Paiva Fernandes (author)
Format: article
Language:por
Published: 2019
Subjects:
24-Cholesterol hydroxylase
Ataxia
Autophagy
Cholesterol metabolism
SCA animal models
SCA patients
Adult
Animals
Brain
Cholesterol
Disease Models, Animal
Female
Humans
Machado-Joseph Disease
Male
Mice, Transgenic
Middle Aged
Nerve Tissue Proteins
Purkinje Cells
Spinocerebellar Ataxias
Online Access:http://hdl.handle.net/10316/92025
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/92025

Internet

http://hdl.handle.net/10316/92025

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