The uptake, retention and clearance of drug-loaded dendrimer nanoparticles in astrocytes - electrophysiological quantification

Nanoparticle-based drug delivery systems may impose risks to patients due to potential toxicity associated with lack of clearance from cells or prolonged carrier-cell retention. This work evaluates vesicular cell uptake, retention and the possible transfer of endocytosed methylprednisolone-loaded ca...

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Bibliographic Details
Main Author: Chowdury, Helena H. (author)
Other Authors: Cerqueira, Susana Isabel Ribeiro (author), Sousa, Nuno (author), Oliveira, J. M. (author), Reis, R. L. (author), Zorec, Robert (author)
Format: article
Language:eng
Published: 2018
Subjects:
Dendrimer nanoparticles
Exocytosis/endocytosis
Astrocytes
High-resolution membrane capacitance
Live confocal imaging
Science & Technology
Online Access:http://hdl.handle.net/1822/51339
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/51339

Internet

http://hdl.handle.net/1822/51339

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