Feedback control of chromosome separation by a midzone Aurora B gradient

Accurate chromosome segregation during mitosis requires the physical separation of sister chromatids before nuclear envelope reassembly (NER). However, how these two processes are coordinated remains unknown. Here, we identified a conserved feedback control mechanism that delays chromosome decondens...

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Bibliographic Details
Main Author: Afonso, O (author)
Other Authors: Matos, I (author), Pereira, AJ (author), Aguiar, P (author), Lampson, MA (author), Maiato, H (author)
Format: article
Language:eng
Published: 2014
Subjects:
Anaphase
Animals
Aurora Kinase B/antagonists & inhibitors
Aurora Kinase B/genetics
Aurora Kinase B/metabolism
Cell Line
Cell Line, Tumor
Chromosome Segregation/genetics
Chromosome Segregation/physiology
Drosophila
Feedback, Physiological
Humans
Nuclear Envelope/genetics
Nuclear Envelope/metabolism
Protein Phosphatase 1/metabolism
Protein Phosphatase 2/metabolism
Online Access:http://hdl.handle.net/10216/110342
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/110342

Internet

http://hdl.handle.net/10216/110342

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