Development and validation of quick Acute Kidney Injury-score (q-AKI) to predict acute kidney injury at admission to a multidisciplinary intensive care unit

AKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models to identify the risk of AKI in ICU patients up to 7 days. We retrospectively recruited 692 consecuti...

ver descrição completa

Detalhes bibliográficos
Autor principal: Ferrari, Fiorenza (author)
Outros Autores: Puci, Mariangela Valentina (author), Ferraro, Ottavia Eleonora (author), Romero-González, Gregorio (author), Husain-Syed, Faeq (author), Rizo-Topete, Lilia (author), Senzolo, Mara (author), Lorenzin, Anna (author), Muraro, Eva (author), Baracca, Antonio (author), Serrano-Soto, Mara (author), Molano Triviño, Alejandra (author), Castro, Ana (author), De Cal, Massimo (author), Corradi, Valentina (author), Brendolan, Alessandra (author), Scarpa, Marta (author), Carta, Maria Rosa (author), Giavarina, Davide (author), Bonato, Raffaele (author), Iotti, Giorgio Antonio (author), Ronco, Claudio (author)
Formato: article
Idioma:eng
Publicado em: 2020
Assuntos:
Intensive Care Units
Texto completo:http://hdl.handle.net/10400.16/2439
País:Portugal
Oai:oai:repositorio.chporto.pt:10400.16/2439
Descrição
Resumo:AKI is associated with increased risk of death, prolonged length of stay and development of de-novo chronic kidney disease. The aim of our study is the development and validation of prediction models to identify the risk of AKI in ICU patients up to 7 days. We retrospectively recruited 692 consecutive patients admitted to the ICU at San Bortolo Hospital (Vicenza, Italy) from 1 June 2016 to 31 March 2017: 455 patients were treated as the derivation group and 237 as the validation group. Candidate variables were selected based on a literature review and expert opinion. Admission eGFR< 90 ml/min /1.73 mq (OR 2.78; 95% CI 1.78-4.35; p<0.001); SOFAcv ≥ 2 (OR 2.23; 95% CI 1.48-3.37; p<0.001); lactate ≥ 2 mmol/L (OR 1.81; 95% CI 1.19-2.74; p = 0.005) and (TIMP-2)•(IGFBP7) ≥ 0.3 (OR 1.65; 95% CI 1.08-2.52; p = 0.019) were significantly associated with AKI. For the q-AKI score, we stratified patients into different AKI Risk score levels: 0-2; 3-4; 5-6; 7-8 and 9-10. In both cohorts, we observed that the proportion of AKI patients was higher in the higher score levels.

Registros relacionados