Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker

The epidermal growth factor receptor (EGFR) is a member of the HER family of growth factors that activates several intracellular signaling pathways promoting proliferation and survival. EGFR over-expression is frequently associated with gene mutation or amplification, thereby constituting a major ta...

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Detalhes bibliográficos
Autor principal: Oliveira, Renato José Silva (author)
Outros Autores: Silva, Viviane Aline Oliveira (author), Martinho, Olga (author), Carloni, Adriana C. (author), Melendez, Matias Eliseo (author), Rosa, Marcela Nunes (author), Paula, Flávia Escremim de (author), Viana, Luciano de Souza (author), Carvalho, André Lopes (author), Reis, R. M. (author)
Formato: article
Idioma:eng
Publicado em: 2016
Assuntos:
EGFR inhibitor
Allitinib
In vitro screening
KRAS mutation
Science & Technology
Texto completo:http://hdl.handle.net/1822/45099
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/45099

Texto Completo

http://hdl.handle.net/1822/45099

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