Cytotoxicity of allitinib, an irreversible anti-EGFR agent, in a large panel of human cancer-derived cell lines: KRAS mutation status as a predictive biomarker

The epidermal growth factor receptor (EGFR) is a member of the HER family of growth factors that activates several intracellular signaling pathways promoting proliferation and survival. EGFR over-expression is frequently associated with gene mutation or amplification, thereby constituting a major ta...

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Bibliographic Details
Main Author: Oliveira, Renato José Silva (author)
Other Authors: Silva, Viviane Aline Oliveira (author), Martinho, Olga (author), Carloni, Adriana C. (author), Melendez, Matias Eliseo (author), Rosa, Marcela Nunes (author), Paula, Flávia Escremim de (author), Viana, Luciano de Souza (author), Carvalho, André Lopes (author), Reis, R. M. (author)
Format: article
Language:eng
Published: 2016
Subjects:
EGFR inhibitor
Allitinib
In vitro screening
KRAS mutation
Science & Technology
Online Access:http://hdl.handle.net/1822/45099
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/45099

Internet

http://hdl.handle.net/1822/45099

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