Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis

Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant.

Bibliographic Details
Main Author: Ruesen, Carolien (author)
Other Authors: Chaidir, Lidya (author), van Laarhoven, Arjan (author), Dian, Sofiati (author), Ganiem, Ahmad Rizal (author), Guimarães, Hanna Nebenzahl (author), Huynen, Martijn A. (author), Alisjahbana, Bachti (author), Dutilh, Bas E. (author), van Crevel, Reinout (author)
Format: article
Language:eng
Published: 2018
Subjects:
Computational Biology
Genomics
Humans
Indonesia
Mycobacterium tuberculosis
Phenotype
Phylogeny
Polymorphism, Single Nucleotide
Tuberculosis, Meningeal
Tuberculosis, Pulmonary
Genes, Bacterial
Genetic Variation
Genome, Bacterial
Pulmonary tuberculosis
Tuberculous meningitis
Whole genome sequencing
Homoplasy
Ciências Médicas::Medicina Básica
Science & Technology
Online Access:http://hdl.handle.net/1822/58062
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/58062

Internet

http://hdl.handle.net/1822/58062

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