Large-scale genomic analysis shows association between homoplastic genetic variation in Mycobacterium tuberculosis genes and meningeal or pulmonary tuberculosis

Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant.

Detalhes bibliográficos
Autor principal:	Ruesen, Carolien (author)
Outros Autores:	Chaidir, Lidya (author), van Laarhoven, Arjan (author), Dian, Sofiati (author), Ganiem, Ahmad Rizal (author), Guimarães, Hanna Nebenzahl (author), Huynen, Martijn A. (author), Alisjahbana, Bachti (author), Dutilh, Bas E. (author), van Crevel, Reinout (author)
Formato:	article
Idioma:	eng
Publicado em:	2018
Assuntos:	Computational Biology Genomics Humans Indonesia Mycobacterium tuberculosis Phenotype Phylogeny Polymorphism, Single Nucleotide Tuberculosis, Meningeal Tuberculosis, Pulmonary Genes, Bacterial Genetic Variation Genome, Bacterial Pulmonary tuberculosis Tuberculous meningitis Whole genome sequencing Homoplasy Ciências Médicas::Medicina Básica Science & Technology
Texto completo:	http://hdl.handle.net/1822/58062
País:	Portugal
Oai:	oai:repositorium.sdum.uminho.pt:1822/58062

Descrição
Resumo:	Meningitis is the most severe manifestation of tuberculosis. It is largely unknown why some people develop pulmonary TB (PTB) and others TB meningitis (TBM); we examined if the genetic background of infecting M. tuberculosis strains may be relevant.