Genome-wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: Fine mapping adds support on chromosomes 6 and 11

As part of an extensive study in the Portuguese Island population of families with multiple patients suffering from bipolar disorder and schizophrenia, we performed an initial genome-wide scan of 16 extended families with bipolar disorder that identified three regions on chromosomes 2, 11, and 19 wi...

Full description

Bibliographic Details
Main Author: Pato, Carlos N. (author)
Other Authors: Pato, M. T. (author), Kirby, A. (author), Petryshen, T. L. (author), Medeiros, H. (author), Carvalho, C. (author), Macedo, A. (author), Dourado, A. (author), Coelho, I. (author), Valente, J. (author), Soares, M. J. (author), Ferreira, C. P. (author), Lei, M. (author), Verner, A. (author), Hudson, T. J. (author), Morley, C. P. (author), Kennedy, J. L. (author), Azevedo, M. H. (author), Daly, M. J. (author), Sklar, P. (author)
Format: article
Language:eng
Published: 2004
Online Access:http://hdl.handle.net/10316/8453
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/8453
Description
Summary:As part of an extensive study in the Portuguese Island population of families with multiple patients suffering from bipolar disorder and schizophrenia, we performed an initial genome-wide scan of 16 extended families with bipolar disorder that identified three regions on chromosomes 2, 11, and 19 with genome-wide suggestive linkage and several other regions, including chromosome 6q, also approached suggestive levels of significance. Dick et al. [2003: Am J Hum Genet 73:107-114] recently reported in a study of 250 families with bipolar disorder a maxLOD score of 3.61 near marker D6S1021 on chromosome 6q. This study replicates this finding having detected a peak NPL = 2.02 (P = 0.025) with the same marker D6S1021(104.7 Mb). Higher-density mapping provided additional support for loci on chromosome 6 including marker D6S1021 with an NPL = 2.59 (P = 0.0068) and peaking at marker D6S1639 (125 Mb) with an NPL = 3.06 (P = 0.0019). A similar pattern was detected with higher-density mapping of chromosome 11 with an NPL = 3.15 (P = 0.0014) at marker D11S1883 (63.1 Mb). Simulations at the density of our fine mapping data indicate that less than 1 scan out of 10 would find two such scores genome-wide in the same scan by chance. Our findings provide additional support for a susceptibility locus for bipolar disorder on 6q, as well as, suggesting the importance of denser scans. Published 2004 Wiley-Liss, Inc.

Similar Items