PINK1/PARKIN signalling in neurodegeneration and neuroinflammation

Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson's disease (PD). PINK1, a protein kinase, and PARKIN, an E3 ubiquitin ligase, control the specific elimination of dysfunctional or superfluous...

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Bibliographic Details
Main Author: Quinn, Peter M. J. (author)
Other Authors: Moreira, Paula I. (author), Ambrósio, António Francisco (author), Alves, C. Henrique (author)
Format: article
Language:eng
Published: 2020
Subjects:
Alzheimer’s disease
Mitophagy
Neurodegeneration
PARKIN
PINK1
Parkinson’s disease
Alzheimer Disease
Amyotrophic Lateral Sclerosis
Animals
Gene Knock-In Techniques
Glaucoma
Humans
Huntington Disease
Inflammation
Macular Degeneration
Mice
Mitochondria
Neurodegenerative Diseases
Parkinson Disease
Protein Kinases
Rats
Signal Transduction
Ubiquitin-Protein Ligases
Online Access:http://hdl.handle.net/10316/101228
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/101228

Internet

http://hdl.handle.net/10316/101228

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