Nanostructured capsules for cartilage tissue engineering

Polymeric multilayered capsules (PMCs) have found great applicability in bioencapsulation, an evolving branch of tissue engineering and regenerative medicine. Here, we describe the production of hierarchical PMCs composed by an external multilayered membrane by layer-by-layer assembly of poly(L-lysi...

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Bibliographic Details
Main Author: Correia, Clara R. (author)
Other Authors: Reis, R. L. (author), Mano, J. F. (author)
Format: bookPart
Language:eng
Published: 2015
Subjects:
Capsules
Chondrogenesis
Microparticles
Stem cells
Bioencapsulation Capsules
Cartilage regeneration
Collagen II
Layer-by-layer
Tissue engineering
TGF-β3
Bioencapsulation
TGF-beta 3
Ciências Médicas::Biotecnologia Médica
Science & Technology
Online Access:http://hdl.handle.net/1822/38386
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/38386
Description
Summary:Polymeric multilayered capsules (PMCs) have found great applicability in bioencapsulation, an evolving branch of tissue engineering and regenerative medicine. Here, we describe the production of hierarchical PMCs composed by an external multilayered membrane by layer-by-layer assembly of poly(L-lysine), alginate, and chitosan. The core of the PMCs is liquified and encapsulates human adipose stem cells and surface functionalized collagen II-TGF-β3 poly(L-lactic acid) microparticles for cartilage tissue engineering.

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