Improving the performance of nadolol stereoisomers' preparative separation using Chiralpak IA by SMB chromatography

The pseudobinary preparative separation of nadolol stereoisomers is performed by simulated moving bed chromatography (SMB). Using the Chiralpak IA adsorbent, a new 25:75:0.1 (v/v/v) methanol-acetonitrile-diethylamine solvent composition was selected to perform the experimental SMB separation and com...

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Bibliographic Details
Main Author: Arafah, Rami (author)
Other Authors: Ribeiro, António E. (author), Rodrigues, Alírio (author)
Format: article
Language:eng
Published: 2018
Subjects:
Chiralpak IA
Nadolol stereoisomers
Optimization of solvent composition
Simulated moving bed
Online Access:http://hdl.handle.net/10198/9279
Country:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/9279

Internet

http://hdl.handle.net/10198/9279

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