Gene expression regulation by upstream open reading frames in rare diseases

Upstream open reading frames (uORFs) constitute a class of cis-acting elements that regulate translation initiation. Mutations or polymorphisms that alter, create or disrupt a uORF have been widely associated with several human disorders, including rare diseases. In this mini-review, we intend to hi...

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Bibliographic Details
Main Author: Silva, Joana (author)
Other Authors: Fernandes, Rafael (author), Romão, Luísa (author)
Format: article
Language:eng
Published: 2018
Subjects:
Upstream Open Reading Frames (uORFs)
Non-AUG Initiation Codon
Translation Initiation
Translational Regulation
Human Rare Disease
Stress
Expressão Génica
Genómica Funcional e Estrutural
Online Access:http://hdl.handle.net/10400.18/5129
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5129

Internet

http://hdl.handle.net/10400.18/5129

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