Glycomic analysis of gastric carcinoma cells discloses glycans as modulators of RON receptor tyrosine kinase activation in cancer

Background Terminal a2-3 and a2-6 sialylation of glycans precludes further chain elongation, leading to the biosynthesis of cancer relevant epitopes such as sialyl-Lewis X (SLe X ). SLe X overexpression is associated with tumor aggressive phenotype and patients' poor prognosis. Methods MKN45 ga...

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Bibliographic Details
Main Author: Mereiter, S (author)
Other Authors: Magalhães, A (author), Adamczyk, B (author), Jin, C (author), Almeida, A (author), Drici, L (author), Ibáñez-Vea, M (author), Gomes, C (author), Ferreira, JA (author), Afonso, L (author), Santos, L (author), Larsen, M (author), Kolarich, D (author), Karlsson, N (author), Reis, CA (author)
Format: article
Language:eng
Published: 2016
Subjects:
Gene Expression Regulation, Enzymologic
Gene Expression Regulation, Neoplastic
Glycomics
Humans
Lewis X Antigen/biosynthesis
Lewis X Antigen/genetics
Neoplasm Proteins/biosynthesis
Neoplasm Proteins/genetics
Polysaccharides/biosynthesis
Polysaccharides/genetics
Receptor Protein-Tyrosine Kinases/genetics
Receptor Protein-Tyrosine Kinases/metabolism
Sialyltransferases/biosynthesis
Sialyltransferases/genetics
Stomach
Neoplasms/genetics
Stomach Neoplasms/metabolism
Online Access:https://hdl.handle.net/10216/119042
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/119042

Internet

https://hdl.handle.net/10216/119042

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