A matrix pencil to the blind source separation of artifacts in 2D NMR spectra

Multidimensional proton nmr spectra of biomolecules dissolved in aqueous solutions are usually contaminated by an intense water artifact. We discuss the application of the generalized eigenvalue decomposition (GEVD) method using a matrix pencil to solve the blind source separation problem of removin...

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Bibliographic Details
Main Author: Stadlthanner, K. (author)
Other Authors: Theis, F. J. (author), Lang, E. W. (author), Tomé, A. M. (author), Gronwald, W. (author), Kalbitzer, H.-R. (author)
Format: article
Language:eng
Published: 2012
Subjects:
Blind source separation
Generalized eigendecomposition
Independent component analysis
Matrix pencil
2D NOESY spectra
Online Access:http://hdl.handle.net/10773/5813
Country:Portugal
Oai:oai:ria.ua.pt:10773/5813
Description
Summary:Multidimensional proton nmr spectra of biomolecules dissolved in aqueous solutions are usually contaminated by an intense water artifact. We discuss the application of the generalized eigenvalue decomposition (GEVD) method using a matrix pencil to solve the blind source separation problem of removing the intense solvent peak and related artifacts. 2D NOESY spectra of simple solutes as well as dissolved proteins are studied.

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