Synthesis, molecular Docking and biological evaluation of new 1-Aryl-3-[3-(thieno[3,2-b]pyridin-7-ylthio)phenylureas as Potent Type II VEGFR-2 Tyrosine Kinase inhibitors

The vascular endothelial growth factor receptor 2 (VEGFR-2) is a tyrosine kinase receptor, expressed primarily in endothelial cells, and is activated by the specific binding of VEGF to the VEGFR-2 extracellular regulatory domain. Once activated, VEGFR-2 undergoes autophosphorylation, triggering sign...

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Bibliographic Details
Main Author: Machado, Vera A. (author)
Other Authors: Peixoto, Daniela (author), Costa, Raquel (author), Calhelha, Ricardo C. (author), Abreu, Rui M.V. (author), Ferreira, Isabel C.F.R. (author), Soares, Raquel (author), Queiroz, Maria João R.P. (author)
Format: conferenceObject
Language:eng
Published: 2015
Online Access:http://hdl.handle.net/10198/12280
Country:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/12280

Internet

http://hdl.handle.net/10198/12280

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