Mycolactone-mediated inhibition of tumor necrosis factor production by macrophages infected with Mycobacterium ulcerans has implications for the control of infection

The pathogenicity of Mycobacterium ulcerans, the agent of Buruli ulcer, depends on the cytotoxic exotoxin mycolactone. Little is known about the immune response to this pathogen. Following the demonstration of an intracellular growth phase in the life cycle of M. ulcerans, we investigated the produc...

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Bibliographic Details
Main Author: Torrado, Egídio (author)
Other Authors: Adusumilli, Sarojini (author), Fraga, Alexandra Gabriel (author), Small, Pamela L. C. (author), Castro, António G. (author), Pedrosa, Jorge (author)
Format: article
Language:eng
Published: 2007
Subjects:
Animals
Bacterial Toxins
Cells, Cultured
Chemokine CXCL2
Disease Models, Animal
Female
Foot
Macrolides
Macrophages
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Monokines
Mycobacterium Infections, Nontuberculous
Mycobacterium ulcerans
Receptors, Tumor Necrosis Factor, Type I
Tumor Necrosis Factor Decoy Receptors
Tumor Necrosis Factor-alpha
Virulence
Science & Technology
Online Access:http://hdl.handle.net/1822/67770
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/67770

Internet

http://hdl.handle.net/1822/67770

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