Functional genomics and biochemical characterization of the C. elegans orthologue of the Machado-Joseph disease protein ataxin-3

Machado-Joseph disease (MJD) is the most common dominant spinocerebellar ataxia. MJD is caused by a CAG trinucleotide expansion in the ATXN3 gene, which encodes a protein named ataxin-3. Ataxin-3 has been proposed to act as a deubiquitinating enzyme in the ubiquitin-proteasome pathway and to be invo...

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Detalhes bibliográficos
Autor principal: Rodrigues, Ana João (author)
Outros Autores: Coppola, Giovanni (author), Santos, Cláudia (author), Costa, Maria do Carmo (author), Ailion, Michael (author), Sequeiros, Jorge (author), Geschwind, Daniel H. (author), Maciel, P. (author)
Formato: article
Idioma:eng
Publicado em: 2007
Assuntos:
Amino acid sequence
Animals
Animals, Genetically modified
Ataxin-3
Caenorhabditis elegans
Caenorhabditis elegans proteins
Cloning, Molecular
Humans
Machado-Joseph disease
Molecular sequence data
Nerve tissue proteins
Peptides
Proteasome endopeptidase complex
Sequence homology, Amino acid
Signal transduction
Ubiquitin
Genomics
Polyglutamine disorders
Ubiquitin-proteasome pathway
Microarray
Ataxia
Knockout
Science & Technology
Texto completo:http://hdl.handle.net/1822/67807
País:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/67807

Texto Completo

http://hdl.handle.net/1822/67807

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