International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

This work was funded by Cohen Veterans Bioscience, the NIMH/U.S. Army Medical Research and Materiel Command Grant R01MH106595 to C.M.N., I.L., K.J.R. and K.C.K., One Mind, and supported by 5U01MH109539 to the Psychiatric Genomics Consortium. Statistical Analysis were carried out on the NL Genetic Cl...

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Main Author: Nievergelt, Caroline M. (author)
Other Authors: Maihofer, Adam X. (author), Klengel, Torsten (author), Atkinson, Elizabeth G. (author), Chen, Chia Yen (author), Choi, Karmel W. (author), Coleman, Jonathan R.I. (author), Dalvie, Shareefa (author), Duncan, Laramie E. (author), Gelernter, Joel (author), Levey, Daniel F. (author), Logue, Mark W. (author), Polimanti, Renato (author), Provost, Allison C. (author), Ratanatharathorn, Andrew (author), Stein, Murray B. (author), Torres, Katy (author), Aiello, Allison E. (author), Almli, Lynn M. (author), Amstadter, Ananda B. (author), Andersen, Søren B. (author), Andreassen, Ole A. (author), Arbisi, Paul A. (author), Ashley-Koch, Allison E. (author), Austin, S. Bryn (author), Avdibegovic, Esmina (author), Babić, Dragan (author), Bækvad-Hansen, Marie (author), Baker, Dewleen G. (author), Beckham, Jean C. (author), Bierut, Laura J. (author), Bisson, Jonathan I. (author), Boks, Marco P. (author), Bolger, Elizabeth A. (author), Børglum, Anders D. (author), Bradley, Bekh (author), Brashear, Megan (author), Breen, Gerome (author), Bryant, Richard A. (author), Bustamante, Angela C. (author), Bybjerg-Grauholm, Jonas (author), Calabrese, Joseph R. (author), Caldas-de-Almeida, José M. (author), Dale, Anders M. (author), Daly, Mark J. (author), Daskalakis, Nikolaos P. (author), Deckert, Jürgen (author), Delahanty, Douglas L. (author), Dennis, Michelle F. (author), Disner, Seth G. (author), Domschke, Katharina (author), Dzubur-Kulenovic, Alma (author), Erbes, Christopher R. (author), Evans, Alexandra (author), Farrer, Lindsay A. (author), Feeny, Norah C. (author), Flory, Janine D. (author), Forbes, David (author), Franz, Carol E. (author), Galea, Sandro (author), Garrett, Melanie E. (author), Gelaye, Bizu (author), Geuze, Elbert (author), Gillespie, Charles (author), Uka, Aferdita Goci (author), Gordon, Scott D. (author), Guffanti, Guia (author), Hammamieh, Rasha (author), Harnal, Supriya (author), Hauser, Michael A. (author), Heath, Andrew C. (author), Hemmings, Sian M.J. (author), Hougaard, David Michael (author), Jakovljevic, Miro (author), Jett, Marti (author), Johnson, Eric Otto (author), Jones, Ian (author), Jovanovic, Tanja (author), Qin, Xue Jun (author), Junglen, Angela G. (author), Karstoft, Karen Inge (author), Kaufman, Milissa L. (author), Kessler, Ronald C. (author), Khan, Alaptagin (author), Kimbrel, Nathan A. (author), King, Anthony P. (author), Koen, Nastassja (author), Kranzler, Henry R. (author), Kremen, William S. (author), Lawford, Bruce R. (author), Lebois, Lauren A.M. (author), Lewis, Catrin E. (author), Linnstaedt, Sarah D. (author), Lori, Adriana (author), Lugonja, Bozo (author), Luykx, Jurjen J. (author), Lyons, Michael J. (author), Maples-Keller, Jessica (author), Marmar, Charles (author), Martin, Alicia R. (author), Martin, Nicholas G. (author), Maurer, Douglas (author), Mavissakalian, Matig R. (author), McFarlane, Alexander (author), McGlinchey, Regina E. (author), McLaughlin, Katie A. (author), McLean, Samuel A. (author), McLeay, Sarah (author), Mehta, Divya (author), Milberg, William P. (author), Miller, Mark W. (author), Morey, Rajendra A. (author), Morris, Charles Phillip (author), Mors, Ole (author), Mortensen, Preben B. (author), Neale, Benjamin M. (author), Nelson, Elliot C. (author), Nordentoft, Merete (author), Norman, Sonya B. (author), O'Donnell, Meaghan (author), Orcutt, Holly K. (author), Panizzon, Matthew S. (author), Peters, Edward S. (author), Peterson, Alan L. (author), Peverill, Matthew (author), Pietrzak, Robert H. (author), Polusny, Melissa A. (author), Rice, John P. (author), Ripke, Stephan (author), Risbrough, Victoria B. (author), Roberts, Andrea L. (author), Rothbaum, Alex O. (author), Rothbaum, Barbara O. (author), Roy-Byrne, Peter (author), Ruggiero, Ken (author), Rung, Ariane (author), Rutten, Bart P.F. (author), Saccone, Nancy L. (author), Sanchez, Sixto E. (author), Schijven, Dick (author), Seedat, Soraya (author), Seligowski, Antonia V. (author), Seng, Julia S. (author), Sheerin, Christina M. (author), Silove, Derrick (author), Smith, Alicia K. (author), Smoller, Jordan W. (author), Sponheim, Scott R. (author), Stein, Dan J. (author), Stevens, Jennifer S. (author), Sumner, Jennifer A. (author), Teicher, Martin H. (author), Thompson, Wesley K. (author), Trapido, Edward (author), Uddin, Monica (author), Ursano, Robert J. (author), van den Heuvel, Leigh Luella (author), Van Hooff, Miranda (author), Vermetten, Eric (author), Vinkers, Christiaan H. (author), Voisey, Joanne (author), Wang, Yunpeng (author), Wang, Zhewu (author), Werge, Thomas (author), Williams, Michelle A. (author), Williamson, Douglas E. (author), Winternitz, Sherry (author), Wolf, Christiane (author), Wolf, Erika J. (author), Wolff, Jonathan D. (author), Yehuda, Rachel (author), Young, Ross Mc D. (author), Young, Keith A. (author), Zhao, Hongyu (author), Zoellner, Lori A. (author), Liberzon, Israel (author), Ressler, Kerry J. (author), Haas, Magali (author), Koenen, Karestan C. (author)
Format: article
Language:eng
Published: 2019
Subjects:
Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)
Online Access:http://hdl.handle.net/10362/89811
Country:Portugal
Oai:oai:run.unl.pt:10362/89811
Description
Summary:This work was funded by Cohen Veterans Bioscience, the NIMH/U.S. Army Medical Research and Materiel Command Grant R01MH106595 to C.M.N., I.L., K.J.R. and K.C.K., One Mind, and supported by 5U01MH109539 to the Psychiatric Genomics Consortium. Statistical Analysis were carried out on the NL Genetic Cluster computer (URL) hosted by SURFsara. Genotyping of samples was supported in part through the Stanley Center for Psychiatric Genetics at the Broad Institute of MIT and Harvard. This research has been conducted using the UK biobank resource under application number 16577. This work would not have been possible without the contributions of the investigators who comprise the PGC-PTSD working group, and especially the more than 206,000 research participants worldwide who shared their life experiences and biological samples with PGC-PTSD investigators. Full acknowledgements are in the Supplementary Note 2.

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