Brain expression of inflammatory mediators in Mesial Temporal Lobe Epilepsy patients

Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1β and IL-10 gene expression as well as the presence of activated HLA-DR+ microglia wa...

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Bibliographic Details
Main Author: Leal, Bárbara (author)
Other Authors: Chaves, João (author), Carvalho, Cláudia (author), Rangel, Rui (author), Santos, Agostinho (author), Bettencourt, Andreia (author), Lopes, João (author), Ramalheira, João (author), Silva, Berta M. (author), da Silva, António Martins (author), Costa, Paulo P. (author)
Format: article
Language:eng
Published: 2021
Subjects:
Adult
Brain
Cytokines
Epilepsy, Temporal Lobe
Female
HLA-DR Antigens
Humans
Male
Microglia
Middle Aged
Toll-Like Receptor 4
Young Adult
Doenças Genéticas
Online Access:http://hdl.handle.net/10400.18/5430
Country:Portugal
Oai:oai:repositorio.insa.pt:10400.18/5430
Description
Summary:Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1β and IL-10 gene expression as well as the presence of activated HLA-DR+ microglia was evaluated in 23 patients and 10 cadaveric controls. Inflammation characterized by the presence of HLA-DR+microglia and TLR4, IL-1β overexpression was evident in hippocampus and anterior temporal cortex of MTLE-HS patients. Anti-inflammatory IL-10 was also overexpressed in MTLE-HS patients. Our results show that hippocampal neuroinflammation extends beyond lesional limits, as far as the anterior temporal cortex.

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