1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as VEGFR-2 tyrosine kinase inhibitors: Synthesis, biological evaluation, and molecular modelling studies

The Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) is a tyrosine kinase receptor involved in the growth and differentiation of endothelial cells that is implicated in tumor-associated angiogenesis. In this study novel 1-aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas were synthesized...

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Bibliographic Details
Main Author: Soares, Pedro (author)
Other Authors: Costa, Raquel (author), Froufe, Hugo J.C. (author), Calhelha, Ricardo C. (author), Peixoto, Daniela (author), Abreu, Rui M.V. (author), Ferreira, Isabel C.F.R. (author), Soares, Raquel (author), Queiroz, Maria João R.P. (author)
Format: article
Language:eng
Published: 2013
Subjects:
Thienopyrimidine ether ureas
VEGFR-2 inhibitors
HUVECs
Western-blot
Molecular modelling
Online Access:http://hdl.handle.net/10198/8554
Country:Portugal
Oai:oai:bibliotecadigital.ipb.pt:10198/8554

Internet

http://hdl.handle.net/10198/8554

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