A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β -Synthase

The human disease classical homocystinuria results from mutations in the gene encoding the pyridoxal 5′-phosphate- (PLP-) dependent cystathionine β-synthase (CBS), a key enzyme in the transsulfuration pathway that controls homocysteine levels, and is a major source of the signaling molecule hydrogen...

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Bibliographic Details
Main Author: Vicente, João B. (author)
Other Authors: Colaço, Henrique G. (author), Malagrinò, Francesca (author), Santo, Paulo E. (author), Gutierres, André (author), Bandeiras, Tiago M. (author), Leandro, Paula (author), Brito, José A. (author), Giuffrè, Alessandro (author)
Format: article
Language:eng
Published: 2019
Subjects:
Biochemistry
Ageing
Cell Biology
SDG 3 - Good Health and Well-being
Online Access:http://hdl.handle.net/10362/85146
Country:Portugal
Oai:oai:run.unl.pt:10362/85146

Internet

http://hdl.handle.net/10362/85146

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