Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase

Cyclic ADP-ribose (cADPR) metabolism in mammals is catalyzed by NAD glycohydrolases (NADases) that, besides forming ADP-ribose, form and hydrolyze the N1-glycosidic linkage of cADPR. Thus far, no cADPR phosphohydrolase was known. We tested rat ADP-ribose/CDP-alcohol pyrophosphatase (ADPRibase-Mn) an...

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Detalhes bibliográficos
Autor principal: Canales, J (author)
Outros Autores: Fernández, A (author), Rodrigues, JR (author), Ferreira, R (author), Meireles Ribeiro, J (author), Cabezas, A (author), Costas, MJ (author), Cameselle, JC (author)
Formato: article
Idioma:por
Publicado em: 2012
Assuntos:
Cyclic ADP-ribose
ADP-ribose
Pyrophosphatase
Phosphoribosyl-AMP
Histidine biosynthesis
Immune signaling
Texto completo:http://hdl.handle.net/10174/5804
País:Portugal
Oai:oai:dspace.uevora.pt:10174/5804

Texto Completo

http://hdl.handle.net/10174/5804

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