High-selectivity optical detection in microfluidic systems for clinical diagnostics
This paper presents a microfluidic system for determining the protein concentrations in human biological fluids (e.g. urine, blood or serum) with a highly sensitive and selective optical photodetector based on a Fabry-Perot filter. The microsystem consists of two wafers: a Pyrex glass wafer containi...
| Main Author: | |
|---|---|
| Other Authors: | , |
| Format: | conferencePaper |
| Language: | eng |
| Published: |
2000
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/1822/2352 |
| Country: | Portugal |
| Oai: | oai:repositorium.sdum.uminho.pt:1822/2352 |
| Summary: | This paper presents a microfluidic system for determining the protein concentrations in human biological fluids (e.g. urine, blood or serum) with a highly sensitive and selective optical photodetector based on a Fabry-Perot filter. The microsystem consists of two wafers: a Pyrex glass wafer containing the microlaboratory (microchannels to carry chemical reagents and sample solutions) and a silicon wafer that includes the protein detection system and readout electronics. The optical channel operates in the visible spectral range. A FWHM < 3 nm and finesse of 36 for narrow band operation is demonstrated in albumin concentration detection. Detection system compensation techniques are also presented. |
|---|