Doxorubicin-induced persistent oxidative stress to cardiac myocytes

We recently reported a cardioselective and cumulative oxidation of cardiac mitochondrial DNA (mtDNA) following subchronic administration of doxorubicin to rats. The mtDNA adducts persist for up to 5 weeks after cessation of doxorubicin treatment. Since the evidence suggests that this persistence of...

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Bibliographic Details
Main Author: Zhou, Shaoyu (author)
Other Authors: Palmeira, Carlos M. (author), Wallace, Kendall B. (author)
Format: article
Language:eng
Published: 2001
Subjects:
Cardiac myocytes
Doxorubicin
Glutathione
Protein-thiol
Reactive oxygen species
Online Access:http://hdl.handle.net/10316/5430
Country:Portugal
Oai:oai:estudogeral.sib.uc.pt:10316/5430

Internet

http://hdl.handle.net/10316/5430

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