Regucalcin is an androgen-target gene in the rat prostate modulating cell-cycle and apoptotic pathways

Regucalcin (RGN) is a calcium (Ca(2+) )-binding protein underexpressed in prostate adenocarcinoma comparatively to non-neoplastic prostate or benign prostate hyperplasia cases. Moreover, RGN expression is negatively associated with the cellular differentiation of prostate adenocarcinoma, suggesting...

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Bibliographic Details
Main Author: Vaz, C V (author)
Other Authors: Baptista, Cláudio (author), Marques, Ricardo (author), Gomes, Inês M (author), Correia, Sara (author), Alves, Marco G (author), Cavaco, JE (author), Oliveira, Pedro F (author), Socorro, Sílvia (author)
Format: article
Language:eng
Published: 2019
Subjects:
Androgen
Apoptosis
Proliferation
Prostate
Regucalcin
Online Access:http://hdl.handle.net/10400.6/7649
Country:Portugal
Oai:oai:ubibliorum.ubi.pt:10400.6/7649
Description
Summary:Regucalcin (RGN) is a calcium (Ca(2+) )-binding protein underexpressed in prostate adenocarcinoma comparatively to non-neoplastic prostate or benign prostate hyperplasia cases. Moreover, RGN expression is negatively associated with the cellular differentiation of prostate adenocarcinoma, suggesting that loss of RGN may be associated with tumor onset and progression. However, the RGN actions over the control of prostate cell growth have not been investigated.

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