Peptaibolin analogues by incorporation of α,α-dialkylglycines: synthesis and study of their membrane permeating ability

Analogues of Peptaibolin, a peptaibol with antibiotic activity, incorporating α,α-dialkylglycines (Deg, Dpg, and Ac6c) at selected positions were synthesised by MW-SPPS and fully characterized. A control analogue incorporating L-alanine was also prepared. The native peptide and the analogues were st...

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Bibliographic Details
Main Author: Castro, Vânia I. B. (author)
Other Authors: Carvalho, Carina Martins (author), Fernandes, Rui D. V. (author), Pereira-Lima, Sílvia M. M. A. (author), Castanheira, Elisabete M. S. (author), Costa, Susana P. G. (author)
Format: article
Language:eng
Published: 2016
Subjects:
alpha,alpha-Dialkylglycines
Peptaibolin
Membrane permeating peptides
Model membranes
Fluorescence spectroscopy
Ciências Naturais::Ciências Físicas
Science & Technology
Online Access:http://hdl.handle.net/1822/39800
Country:Portugal
Oai:oai:repositorium.sdum.uminho.pt:1822/39800

Internet

http://hdl.handle.net/1822/39800

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