Preventing E-cadherin aberrant N-glycosylation at Asn-554 improves its critical function in gastric cancer

E-cadherin is a central molecule in the process of gastric carcinogenesis and its posttranslational modifications by N-glycosylation have been described to induce a deleterious effect on cell adhesion associated with tumor cell invasion. However, the role that site-specific glycosylation of E-cadher...

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Bibliographic Details
Main Author: Carvalho, S (author)
Other Authors: Catarino, TA (author), Dias, A (author), Kato, M (author), Almeida, A (author), Hessling, B (author), Figueiredo, J (author), Gärtner, F (author), Sanches, J (author), Ruppert, T (author), Miyoshi, E (author), Pierce, M (author), Carneiro, F (author), Kolarich, D (author), Seruca, R (author), Yamaguchi, Y (author), Taniguchi, N (author), Reis, CA (author), Pinho, SS (author)
Format: article
Language:eng
Published: 2016
Subjects:
Amino Acid Sequence
Animals
Asparagine/genetics
Cadherins/chemistry
Cadherins/genetics
Cadherins/metabolism
Cadherins/physiology
Catalytic Domain/genetics
Cell Line, Tumor
Dogs
Gastric Mucosa/metabolism
Gastric Mucosa/pathology
Glycosylation
HT29 Cells
Humans
Madin Darby Canine Kidney Cells
Mice
Mice, Inbred C57BL
Mice, Knockout
Molecular Sequence Data
Mutagenesis, Site-Directed
N-Acetylglucosaminyltransferases/antagonists & inhibitors
N-Acetylglucosaminyltransferases/genetics
N-Acetylglucosaminyltransferases/metabolism
Sequence Homology, Amino Acid
Stomach Neoplasms/genetics
Stomach Neoplasms/metabolism
Stomach Neoplasms/pathology
Online Access:https://repositorio-aberto.up.pt/handle/10216/118212
Country:Portugal
Oai:oai:repositorio-aberto.up.pt:10216/118212

Internet

https://repositorio-aberto.up.pt/handle/10216/118212

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